A recent clinical trial published in The Lancet Infectious Diseases has shown promising results for using metformin as a potential treatment for preventing long Covid. The trial, named COVID-OUT, aimed to investigate whether taking metformin during the acute phase of a SARS-CoV-2 infection could reduce the risk of long Covid development. The trial was conducted at six different locations in the United States, with study participants randomly assigned to one of six treatment combinations, including metformin plus placebo and fluvoxamine plus placebo. Results showed that those taking metformin were 41% less likely to develop long Covid than those taking only a placebo. Metformin has been used to treat diabetes for many years, and its effectiveness against Covid-19 may be related to its ability to decrease the amount of glucose produced by the liver and increase the insulin response of the body tissues. While promising, it’s important to note that more research is needed before metformin can be established as a treatment for long Covid.
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