AMG-1/SLRP-1 is required for spermatogenesis in C. elegans: Study

The understanding of the mechanisms underlying post-transcriptional regulation of pre-existing mRNAs by RNA-binding proteins (RBPs) for spermatogenesis is currently limited.

However, a recent study conducted by researchers at Beijing Normal University sheds light on this topic. The study reveals the crucial role of a germline-specific mitochondrial RBP called AMG-1 (abnormal mitochondria in germline 1), which is a homolog of mammalian leucine-rich PPR motif-containing protein (LRPPRC), in spermatogenesis in Caenorhabditis elegans.

The researchers found that the amg-1 mutation affects germline development and leads to abnormal mitochondrial morphology and structure in the germline. They also discovered that AMG-1 predominantly binds to mtDNA-encoded 12S and 16S ribosomal RNA, which are essential components of mitochondrial ribosomes. Notably, AMG-1-mediated expression of 12S rRNA plays a crucial role in maintaining germline mitochondrial protein homeostasis.

Additionally, the study identified the interaction between AMG-1 and another RNA-binding protein called SLRP-1 (steroid receptor RNA activator [SRA] stem loop interacting RNA binding protein), a homolog of mammalian SLIRP (SRA stem loop interacting RNA binding protein) in C. elegans. This interaction genetically regulates germline development and reproductive success in the nematode.

The findings of this study provide valuable insights into the novel function of mitochondrial RBPs in the regulation of germline development.

The study, led by Prof. Long Miao from Beijing Normal University, has been published in the journal Science Bulletin.

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