Home Science Near-Reality: Non-hallucinogenic Psychedelic Drugs for Depression Treatment on the Horizon

Near-Reality: Non-hallucinogenic Psychedelic Drugs for Depression Treatment on the Horizon

Scientists have discovered a promising new method of treating depression using LSD and psilocin that does not involve hallucinations. These drugs affect a specific receptor in the brain, inducing antidepressant-like effects. Previous studies have shown that these compounds can relieve depression, but their hallucinogenic properties have limited their clinical use. Until recently, it was thought that their antidepressant and hallucinogenic effects were both due to serotonin receptor activation. However, a lab study found that LSD and psilocin bind to a molecule in the brain called the neurotrophic receptor tyrosine kinase (TrkB), which produces the antidepressant-like effects. This discovery paves the way for the development of new drugs that have fast and long-lasting antidepressant effects, without the hallucinogenic features of LSD and psilocin.

 

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