Home Science The Impact of Smoke Exposure on Brain Function

The Impact of Smoke Exposure on Brain Function

JERSEY CITY, NJ – June 7: The sun rises behind the magnificent Manhattan skyline and One World Trade Center in New York City, but unfortunately, it is shrouded in smoke. This smoke is a result of the Canadian wildfires, which have caused the National Weather Service to issue warnings to more than 80 million Americans across the Midwest, Northeast, and Appalachian Mountains. These warnings advise people to limit their outdoor activities and exposure to the smoke. The Canadian wildfires have had a widespread impact, with Toronto experiencing the worst air quality of any major city in the world. Tens of millions of people in both the U.S. and Canada are affected by this ongoing wildfire season.

Apart from the immediate dangers of the fires themselves, the health effects of exposure to wildfire smoke are a growing concern. Even at large distances, the smoke can have significant effects on the brain and cognition in just a few hours. Particulate matter (PM), produced by the inefficient burning of wildfires, enters the air and eventually the body, causing adverse effects on brain health and memory. Although there are only a few scientific studies on the specific effects of wildfire smoke on the brain, it is expected to be an area of increasing research as wildfires become more intense and frequent.

The chemical composition of wildfire smoke PM differs from ambient PM or pollution from other sources. Wildfire PM contains more carbon-based pollutants and a mix of particulates of different sizes depending on the ecological source of the fire. These particulates can reach the brain through inhalation via the lungs or the olfactory neurons in the nose. Systemic inflammation resulting from smoke exposure can increase the permeability of the blood-brain barrier, allowing PM to cross and reach the brain. Once in the brain, ambient PM has been shown to cause oxidative toxicity, cell death, and inflammation. Similar effects are expected from PM produced by wildfires.

A recent study on mice exposed to wildfire smoke inhalation found significant and persistent neuroinflammation, as well as changes in specific molecules in the blood and brain. The study also observed an increase in amyloid-beta protein, associated with neurodegenerative disorders like Alzheimer’s Disease. There is also a statistical correlation between short-term acute exposure to wildfire smoke PM and decreased cognitive performance. Additionally, experiencing a wildfire has been shown to have severe mental health effects such as anxiety, depression, and traumatic stress.

The long-term effects of acute wildfire smoke exposure on brain health and cognition are still unknown. However, as wildfires worsen over time, it is conceivable that the effects on affected individuals’ brains could become more severe in the coming decades.

 

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