A team of researchers at the Max Planck Institute for Heart and Lung Research, working with a colleague from Temple University, has found that transcriptional adaptation appears to play a role in inherited epigenetic changes.
In their study, published in the journal Science Advances, the group conducted mutant messenger (mRNA) degradation experiments with nematodes and zebrafish.
Prior research has shown that people can inherit traits from their parents that are not due to genetic sequences—instead, the traits are passed down epigenetically. Such instances are mainly due to environmental factors, such as stress during pregnancy or malnutrition. In this new effort, the researchers found that there may be other ways it can happen, such as via a process they call transcriptional adaptation, in which epigenetic changes might be directed due to mutations in a parental genome.
Suspecting that non-genetic traits can be passed from parent to offspring due to a mutation in a parent that increases the expression of other kinds of genes, the researchers conducted experiments with nematodes and zebra fish.
They began by breeding nematodes with a single copy of a mutated act-5 gene—each also had a functional copy. Prior research had shown that act-5 pushes protein expression from the act-3 gene. The researchers altered the gene to make the protein fluorescent red to make it easy to see in tests. The researchers chose to study act-3 because it is normally only expressed in the pharynx. But when there was a mutated act-5 gene, the protein was expressed in the intestine.
Testing showed the intestines of offspring also lighting up with red protein, despite having no mutated act-5 genes, an example of transcriptional adaptation. The researchers also found that the red intestinal trait lasted for up to six generations. The researchers then repeated roughly the same experiment with zebrafish to find out if inherited transcriptional adaptation can also happen with vertebrates and found roughly the same results.
The researchers suggest that transcriptome traits can come from both mutations inherited from their parents and also from those that are not inherited.
More information:
Zhen Jiang et al, Parental mutations influence wild-type offspring via transcriptional adaptation, Science Advances (2022). DOI: 10.1126/sciadv.abj2029
© 2022 Science X Network
Citation:
Transcriptional adaptation found to play a role in inherited epigenetic changes (2022, December 29)
retrieved 29 December 2022
from https://phys.org/news/2022-12-transcriptional-play-role-inherited-epigenetic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
